Medication evidence profile
Difemerine
Clinical overview
Difemerine has public medication-list entries in KABS 2020 open validation supplement and CALS 2022 Table 4. These are 2 separate source versions, each with its own evidence and definitions.
Source-specific scores
| Source | Score |
|---|---|
| JARS | Not listed |
| Yamada-ABS | Not listed |
| BAAS | Not listed |
| Swe-ABS | Not listed |
| GABS | Not listed |
| KABS | 3 |
| CALS | 3 |
How to read this: 0 means the source explicitly assigned zero. “Not listed” means the source did not provide a score for this medication. Scores from different scales are not averaged.
How to interpret the evidence
2 of 7 public source versions contain an explicit medication-list entry for difemerine.
The available rows for difemerine display the same numeric value. Agreement of the displayed numbers does not establish identical methods, clinical meaning or patient-level risk.
None of the public rows in this profile is an explicit zero. An unlisted source still supplies no value.
Source labels and provenance · 2 observations
- KABS 2019 scale - 2020 open validation supplement
Source label: Difemerine. Published value: 3.
Source version: KABS-2020-validation-supplement
Source location: Additional file 1; category Drugs for gastrointestinal conditions and disorders; table row 70
Observation: KABS2020_SUPP_0357; rating state: published_validation_supplement_rating. - CALS 2022 - primary final Table 4
Source label: Difemerine. Published value: 3.
Source version: CALS-2022-primary-table4
Source location: Table 4; literal capture row 167; displayed table row 24; displayed column 6
Observation: CALS2022_T4_0167; rating state: published_final_table_rating.
What this page does not establish
- No medication-list entry is available here from JARS 2025, Yamada-ABS 2023, BAAS 2019, Swe-ABS 2023, and GABS 2018. These gaps remain “Not listed”; no score is inferred from another source or from class membership.
- No route inference unless present in the source label.
- These source records do not estimate an individual’s probability of harm or establish whether to start, stop or change a medication. Ordinal source scores are not averaged into a UnifiedACB score.
References
- Suh Y, Ah YM, Han E, et al. Dose response relationship of cumulative anticholinergic exposure with incident dementia: validation study of Korean anticholinergic burden scale. BMC Geriatr. 2020;20(1):265. doi:10.1186/s12877-020-01671-z. Open source
- Ramos H, Moreno L, Pérez-Tur J, Cháfer-Pericás C, García-Lluch G, Pardo J. CRIDECO Anticholinergic Load Scale: an updated anticholinergic burden scale. Comparison with the ACB Scale in Spanish individuals with subjective memory complaints. J Pers Med. 2022;12(2):207. doi:10.3390/jpm12020207. Open source
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