Medication evidence profile
Piprinhydrinate ; diphenylpyraline
Clinical overview
Piprinhydrinate ; diphenylpyraline has public medication-list entries in JARS 2025 and KABS 2020 open validation supplement. These are 2 separate source versions, each with its own evidence and definitions.
Source-specific scores
| Source | Score |
|---|---|
| JARS | 3 |
| Yamada-ABS | Not listed |
| BAAS | Not listed |
| Swe-ABS | Not listed |
| GABS | Not listed |
| KABS | 3 |
| CALS | Not listed |
How to read this: 0 means the source explicitly assigned zero. “Not listed” means the source did not provide a score for this medication. Scores from different scales are not averaged.
Other names used in the sources
Diphenylpyraline, Piprinhydrinate, Piprinhydrinate ; diphenylpyraline
How to interpret the evidence
2 of 7 public source versions contain an explicit medication-list entry for piprinhydrinate (diphenylpyraline).
The available rows for piprinhydrinate (diphenylpyraline) display the same numeric value. Agreement of the displayed numbers does not establish identical methods, clinical meaning or patient-level risk.
None of the public rows in this profile is an explicit zero. An unlisted source still supplies no value.
Source labels and provenance · 2 observations
- Japanese Anticholinergic Risk Scale (JARS) 2025 English translation
Source label: Diphenylpyraline. Published value: 3.
Source version: JARS-2025
Source location: RC4 source recovery; recovery_scope=primary_table_complete; ATC=R06AA07
Observation: JARS_2025_R0131; rating state: published_rating. - KABS 2019 scale - 2020 open validation supplement
Source label: Piprinhydrinate ; diphenylpyraline. Published value: 3.
Source version: KABS-2020-validation-supplement
Source location: Additional file 1; category Antihistamines; table row 26
Observation: KABS2020_SUPP_0086; rating state: published_validation_supplement_rating.
Dose, route, and formulation notes
Reviewed canonical identity cluster; 2020 KABS supplement explicitly pairs piprinhydrinate and diphenylpyraline; literal source labels and scores remain source-specific.
What this page does not establish
- No medication-list entry is available here from Yamada-ABS 2023, BAAS 2019, Swe-ABS 2023, GABS 2018, and CALS 2022 Table 4. These gaps remain “Not listed”; no score is inferred from another source or from class membership.
- Do not infer route equivalence; preserve source-specific route/formulation labels.
- These source records do not estimate an individual’s probability of harm or establish whether to start, stop or change a medication. Ordinal source scores are not averaged into a UnifiedACB score.
References
- Mizokami F, Mizuno T, Taguchi R, et al. Development of the Japanese Anticholinergic Risk Scale: English translation of the Japanese article. Geriatr Gerontol Int. 2025;25(1):5-13. doi:10.1111/ggi.15001. Open source
- Suh Y, Ah YM, Han E, et al. Dose response relationship of cumulative anticholinergic exposure with incident dementia: validation study of Korean anticholinergic burden scale. BMC Geriatr. 2020;20(1):265. doi:10.1186/s12877-020-01671-z. Open source
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